CLINICAL EXPERIENCE OF TA-058 IN URINARY TRACT INFECTIONS

Abstract

TA-058 was administered to 84 cases diagnosed as urinary tract infection among out-patients and in-patients of departments of urology of 15 institutes (i. e. Kyushu University and its related university and other hospitals) from July 1981 to January 1982. The patients were treated with 1-2 g of this drug per day in simple urinary infection, 2 g or 4 g per day in complicated urinary tract infection.
In case of simple urinary tract infection, the clinical effects of TA-058 were excellent in 8 cases and good in 2 cases out of 10 cases except for 2 drop out cases (effective rate 100 %). In case of Complicated urinary tract infection, its effects were excellent in 8 cases, good in 21 cases and poor in 38 cases out of 67 cases except for 5 drop out cases (effective rate 43.3 %).
Bacteriologically, 43 strains out of 85 strains isolated from all cases of complicated urinary tract infection were disappeared after treatment with TA-058. This drug was effective for gram positive bacilli, E. coli and P. mirabilis but not for Serratia and Klebsiella.
No side effects were noticed during the treatment with this drug but GOT and GPT elevation col laboratory findings was observed in only one case.