THERAPEUTIC EFFECT OF TA-058 ON LOCAL EXPERIMENTAL INFECTIONS IN MICE
1984 Volume 32 Issue Supplement2 Pages 67-72
Details
1984 Volume 32 Issue Supplement2 Pages 67-72
The therapeutic effects of TA-058 against local experimental infections in mice were compared with those of piperacillin (PIPC) and carbenicillin (CBPC). The following results were obtained.
1. TA-058 was more effective than PIPC and CBPC against experimental urinary tract infections induced by E. coli KC-14 in mice.
2. Against experimental pneumonic infection induced by inhalation of K. pneumontae DT-S in mice, TA-058 excelled PIPC and CBPC in the therapeutic efficacy.
3. With subcutaneous treatment of infected mice, TA-058 decreased viable bacterial cells in the infectious lungs more rapidly than PIPC and CBPC.
4. In subcutaneously administered mice, TA-058 gave higher drug concentrations in the blood, kidney and lung than PIPC and CBPC. These higher concentrations of TA-058 maintained longer than those of PIPC and CBPC.
