FUNDAMENTAL AND CLINICAL STUDIES ON TA-058

IN THE FIELD OF OBSTETRICS AND GYNECOLOGY

Abstract

One gram of TA-058, a parenteral penicillin, was given by intravenous single shot to each of 18 patients who underwent total hysterectomy suffered from myoma of the uterus, and the levels of TA-058 in sera of cubital vena and uterine artery, and cervix, myometrium, endometrium, ovarium and Fallopian tube were determined by bioassay method with E. coil ATCC 27166 and M. luteus ATCC 9341 as the test organisms.
Mean venous serum level after injection of one gram of TA-058 was, 39, 4 μg/ml at 30 min., 25.8μg/ml at 60 min., 23.0 μg/ml at 90 min., 11.3 μg/ml at 120 min., 9.5 μg/ml at 150 mm. and 3.7 μg/ml at 240 min., respectively. Mean serum level of the uterine artery wes nearly equal to mean level of venous serum at the same time.
The rates of tissue levels to serum levels at 30 min. after injection were 56.3 % in cervix, 50.5 % in myornetrium, 45.7 % in endometrium. 51.5% in fallopian tube and 42.0 % in ovarium, respedively.
Clinical effect, was estimated in nine cases, two cases of vaginal cuff abscess, one case of surgical wound infection, three cases of adnexitis and three cases of pelvic peritonitis. TA-058 was given by intravenous injection in five cases and dripping in four cases. Total doses ranged from ten to forty two grams. Clinical effect was obtained good in eight cases and poor in one case of adnexitis. The bacteriological effect was investigated in vivo, and found to be effective, in 57.1 % of all cases.
No adverse reaction was observed in any of the cases treated with TA-058, nor was there any marked changes in the laboratory findings including peripheral blood examinations, hepatic and renal function.