PHARMACOKINETIC STUDY ON TA-058 IN GYNECOLOGY
1984 Volume 32 Issue Supplement2 Pages 727-731
Details
1984 Volume 32 Issue Supplement2 Pages 727-731
Concentration of TA-058 was examined in peripheral vein, uterine artery and genital organs including ovary, oviduct, endorrietrium, myometrium, cervix uteri and portio vaginalis of 45 cases received simple hysterectomy or other gynecological operations. Data were analized by the simulation curves prepared from pharmacokinetic parameters using the two-compartment model.
No marked difference in concentration between peripheral vein and uterine artery was observed after administration of 2g dose intravenously. The half life of the former was 1.4 hours and that of the latter was 2 hours.
The peak level of TA-058 in Those genital organs was attained 34.1 to 58.4 μg/g during 0.21 to 0.52 hours. Some differences in half life among various tissues were observed. They were varied from 0.53 to 1 hours. Area under curves (AUG) of various tissues were achieved about 30 to 50% of that of uterine artery level.
From the above results, it is concluded that the transfer of TA-058 to genital organs was sufficient.
