1984 Volume 32 Issue Supplement2 Pages 737-743
TA-058, a new semisynthetic penicillin derivative, was evaluated to obtaip the following results.
1) The in vitro activities of TA-058 against various strains of clinical isolates were compared with those of piperacillin, sulbenicillin and ampicillin. TA-058 showed relatively same activities as sulbenicillin against S. aureus, K. pneumqniae and S. marcescens. Against E. coli, TA-058 was stronger than sulbenicillin. It was the most active, against P. mirabilis, whereap less active against P.vulgaris.
2) TA-058 was administered to 4 cases of various types of infections, and clinical response was good 2. cases.and poor 2 cases. No serious side effect of adverse reaction was observed.
