FUNDAMENTAL AND CLINICAL STUDIES FOR OPHTHALMIC USE OF TA-058
1984 Volume 32 Issue Supplement2 Pages 775-779
Details
1984 Volume 32 Issue Supplement2 Pages 775-779
Fundamental and clinical studies of TA-058, a new penicillin antibiotic, were performed in the fieradf ophthalmology, and the results obtained were as follows.
1) The bacteriological activities of TA-058 was similar to that of ABPC, CBPC and PIPC.
The distribution of the sensitivity for 20 clinical isolates of S. aureus was in the range of 0.78-12.5μg/ml and the peak were at 0.78 μg/ml and 3.13 μg/ml, and each number of strains were 5 (25 %) respectively. Ten strains of P. aeruginose were sensitive at 25->100 μg/ml and of these five were distributed under 50μg/ml.
2) Ocular penetrations were examined in the rabbit eye. After intravenous injection of 50 mg/kg the aqueous level reached the peak of 6.0 μg/ml after 1/2 hours. Aqueous serum ratio at 30 minutes was 5.28%. The ocular tissue concentrations at 30 minutes after intravenous injection showed high levels in outer parts of the eye and relatively high levels in inner parts.
3) In the clinical study, the intravenous injection or drip infusion of 1.0 g-2.0 g once or twice a day was performed in 14 cases, such as external hordeolum, meibomianitis, acute dacryocystitis, corneal ulcer, corneal abscess, iridocyclitis purulenta, orbital infection. The result obtained was excellent in 5 cases, good in 8 cases and poor in 1 case.
4) No abnormal findings were recognized and no severe side effects were observed.
