Abstract
General pharmacological properties of sulbactam (SBT) and SBT/CPZ were examined.
1. When mice were intravenously treated with SBT at 2, 000mg/kg or SBT/CPZ at1, 000/1, 000mg/kg, there were no significant effects on spontaneous motor activity, motor coordination, grip strength, electroshock-induced convulsion or nociceptive response.
2. In anesthetized dogs, slight and transient increases in respiratory rate and blood pressure were noted after intravenous injection of SBT at 500mg/kg or SBT/CPZ at 500/500mg/kg. There were no effects of SBT and SBT/CPZ on atrial rate or contractile force of isolated guinea pig atria.
3. Intravenous injection of SBT at 2, 000mg/kg or SBT/CPZ at 1, 000/1, 000mg/kg had no effects on pupil size in mice, gastric secretion in Shay rats and nictitating membrane contraction in anesthetized cats.
4. No significant effects of SBT or SBT/CPZ were found in isolated smooth muscle preparations, except for slight increase in spontaneous motility of isolated rabbit ileum at a high concentration of SBT/CPZ (10-3/10-3g/ml).
5. In saline loaded-rats, no significant influences on urine volume or urinary electrolytes excretion were noted with SBT at 1, 000mg/kg or SBT/CPZ at 1, 000/1, 000mg/kg (i. v.), but slight increases in urine volume and urinary Na+ excretion were observed with SBT at 2, 000mg/kg.
