1984 Volume 32 Issue Supplement4 Pages 192-201
We injected bolusly sulbactam 1000mg to 5 healthy male volunteers for the first time in Japan and after 1 week sulbactam 1000mg and cefoperazone 1000mg simultaneously. No abnormal findings of sings or symptoms, physical examinations and laboratory tests were observed after each injection.
A hundred and four μg/ml of peak serum level was obtained 5 minutes after injection of sulbactam 1000mg and was 0.564g/ml 6 hours after injection. Urinary level of sulbactam after 0-1 hour was 9, 820μg/ml and 98.8% of dose was excreted in urine, until 12 hours.
Serum level of cefoperazone after two drug administration was higher than that of sulbactam and prolonged.Urinary excretion of cefoperaozne for 24 hours was 29.3%.
Urinary level until 6 hours of sulbactam was higher than that of cefoperazone, but cefoperaozne was higher than sulbactam after 6 hours in urine.
