IN VITRO EXPERIMENTS ON THE EFFECTS OF SULBACTAM IN COMBINATION WITH CEFOPERAZONE AGAINST CLINICAL ISOLATES OF VARIOUS PATHOGENIC BACTERIA
1984 Volume 32 Issue Supplement4 Pages 20-37
Details
1984 Volume 32 Issue Supplement4 Pages 20-37
We studied the in vitro antibacterial effects of the combination of cefoperazone (CPZ) and sulbactam (SBT), a β-lactamase inhibitor, on clinical isolates of various pathogenic bacteria, i. e., Staphylococcus, Streptococcus faecalis, Hemophilus influenzae, Enterobacteriaceae, glucose non-fermenting Gram-negative rods and Bacteroides.
1) Except for Gram-positive cocci and H. influenzae, a combination effect was evident with all bacterial isolates, especially those with higher MIC's against CPZ, and the antibacterial activity of CPZ was enhanced by the addition of SBT.
2) Some of the isolates were also examined for the production of β-lactamase. Against most of the β-lactamase producing bacteria, the antibacterial activity of CPZ was enhanced by the addition of SBT.
3) In these experiments, the combination effect of CPZ and SBT was greater with the inoculum size of 108 CFU/ml compared to that of 106 CFU/ml.
