LABORATORY AND CLINICAL STUDIES ON SULBACTAM/CEFOPERAZONE COMBINATION

Abstract

Antimicrobial activities of sulbactam/cefoperazone combination (SBT/CPZ) were compared with that of CPZ against the clinically isOlated strains, such as S. aureus, S. epidermidis, S. pneumoniae, α-Streptococcus, S. faecalis, E. coli, Shigella, Salmonella, K. pneumoniae, K. oxytoca, Citrobacter, Enterobacter, Serratia, P. vulgaris, P.mirabilis, P.morganii, P. rettgeri, Rinconstans, H. influenzae, V. parahemolyticus, A. calcoaceticus, Flavobacterium, P. aeruginosa, P. cepack and P. maltophilia.
Except the strains of P. vulgaris and A.calcoaceticus, SBT/CPZ showed similar activity to CPZ. Though SBT/CPZ also showed much stronger activity against A. calcoaceticus than other cephems tested, the merit of combination of sulbactam and CPZ was obscure, because of the strong activity of sulbactam against the strain.
SBT/CPZ was administered to 7 cases of respiratory tract infections (5 cases of bronchopneumonia, one case of lung abscess and one case of chronic bronchitis) and each one case of septicemia, urinary tract infection and FUO. With the exception of the case of septicemia, SBT/CPZ showed good results clinically and bacteriologically.
As for the side effects of the drug, no marked ones were observed.