1984 Volume 32 Issue Supplement4 Pages 66-77
Antibacterial activity of sulbactam (SBT) in combination with cefoperazone (CPZ) against anaerobes was evaluated in vitro and in vivo.
SBT, when combined with CPZ, cefazolin (CEZ), or amoxicillin (AMPC), showed excellent antibacterial activity against anaerobic Gram-negative rods such as Bacteroides fragilis. The combination of SBT and CPZ in a 1:1 ratio had antibacterial activity equal or superior to cefmetazole (CMZ) against anaerobic Gram-negative rods including B. fragilis and Bacteroides thetaiotaomicron, and the activity was bactericidal.
In experimental infection models with mice, the combination of SBT and CPZ showed excellent in vivo antibacterial activity. In addition, the incidence of Clostridium difficile, one of the causative agents of diarrhoea observed after antibiotic administration, was markedly reduced by the combination, compared with the single administration of each drug.
