1984 Volume 32 Issue Supplement9 Pages 127-130
Significance of potentiation of host defense by AC-1370 was investigated in relation to the treatment of infectious diseases. AC-1370 defended mice from Candida albicans infections, though the compound did not show direct antifungal effects on C. albicans. Treatment of mice with cyclophosphamide made the animals susceptible to C. albicans infection, and AC-1370 defended cyclophosphamide-treated mice from C. albicans infection, Furthermore, AC-1370 restored the functions of neutrophils, which had been suppressed by cyclophosphamide treatment in vitro, to the level same as those of intact neutrophils. These results suggest that the potentiating action of AC-1370 on host defense may contribute to the treatment of infections.
