1984 Volume 32 Issue Supplement9 Pages 157-162
The pharrnacokinetics of AC-1370, a new cephalosporin derivative, were investigated in 4 patients and experimental animals with renal insufficiency. In patients, serum and urinary concentrations of AC-1370 were determined by bioassay. In experimental animals, serum, urinary and biliary concentrations of AC-1370 were determined by radioassay.
The following results were obtained.
1) In patients with various degree of renal' impairment, serum levels and half-lives (β) were higher in proportion to highering of serum creatinine, and urinary recovery rates were decreased. There were linear correlations between the creatinine clearance and the elimination rate constant.
2) In experimental renal insufficiency rats, urinary recovery rate and Ccr were 20% and 0.2ml/mm, and these values were lower than those in normal rats (60% and 0.9ml/min), whereas biliary recovery rate was higher than normal rats (6% vs 2%).
