BASIC AND CLINICAL STUDIES ON AC-1370
1984 Volume 32 Issue Supplement9 Pages 207-212
Details
1984 Volume 32 Issue Supplement9 Pages 207-212
AC-1370 was given to 11 patients with respiratory infections (6 cases with pneumonia, 2 cases with pulmonary suppuration, 1 case with pyothorax, 2 cases with secondary infection of chronic lung diseases). The drug was administered intravenously by drip injection twice a day with the doses of 1 or 2 g for 8 to 15 days. The clinical effect to AC-1370 treatment was excellent in 2 cases, good in 6 cases, fair in 2 cases and unevaluable in 1 case.
Side effects with AC-1370 were observed in 2 cases consisting of skin eruption with drug fever and skin eruption, and two cases showed slight elevation of GOT, and of GOT and GPT. The penetration rate of AC-1370 from blood into lung was measured in lung tissues extracted from patients with lung cancer. The average ratios of tissue level vs. serum level were 3 8.2% at 1 hour, 51% at 2 hours, and 55% at 3 hours after administration.
