1984 Volume 32 Issue Supplement9 Pages 264-272
Clinical study of AC-1370, a new cephem derivative, was made in the treatment of respiratory infection including 16 cases of airway and small airway infection, 1 case of empyema and 1 case of pneumonia. As the pneumonia was diagnosed to be due to mycoplasma later, this case was excluded from clinical effect judgement.
The results were obtained as follows:
1) AC-1370 was found to be effective in 71% of 7 cases of airway infection and 67% of 9 cases of small airway infection.
2) AC-1370 showed fine efficacy for the case of empyema due to anaerobic bacteria.
3) AC-1370 showed excellent effect for the infection due to Haemophilus influenzae, Streptococcus pneumoniae and anaerobic bacteria, however, poorly effective for the infection due to Pseudomonas aeruginosa.
4) Although no clinical side effect was caused by AC-1370, eosinophilia in 1 patient and elevation of GOT and GPT in 2 patients were found as abnormal laboratory data after this therapy. Mild elevation of GOT and GPT in one case continued till the 8th day from the cessation of the therapy, but other abnormal findings were alleviated rapidly following cessation of AC-1370.
