CLINICAL STUDIES ON AC-1370 IN RESPIRATORY TRACT INFECTIONS

Abstract

AC-1370, a new cephalosporin antibiotic, was used in the treatment of respiratory tract infections: 12 cases of pneumonia, 1 case of pulmonary suppuration, 6 cases of chronic bronchitis and 4 cases of bronchiectasis. The drug was administered by intravenous drip infusion at a daily dose of 2 g twice a day for the periods of 4 to 14 days.
In eight out of 23 cases, causative bacteria were isolated from sputum.
The clinical efficacy was excellent in 7 cases, good in 9 cases, poor in 3 cases and unevaluable in 3 cases. The rate of efficacy was 85.0%.
Neither side effect nor abnormal laboratory findings attributable to this drug were observed.
The above results suggested that AC-1370 is a useful drug for severe respiratory tract infections.