FUNDAMENTAL AND CLINICAL STUDIES ON AC-1370
1984 Volume 32 Issue Supplement9 Pages 381-386
Details
1984 Volume 32 Issue Supplement9 Pages 381-386
AC-1370, a new cephem antibiotic, was studied bacteriologically and clinically and the following results were obtained:
MICs of AC-1370 was determined against clinical isolates of various species. The peak of MIC distribution curve was observed at 12.5 μg/ml for S. aureus, at 3.13 μg/ml for E. colt, at 100 μg/ml for K. pneumoniae, at 1.56 and not less than 100 μ/ml for P. mirabilis, at 100 μg/ml for P. vulgaris, and at 100 μg/ml for P. aeruginosa.
AC-1370 was administered to 9 patients including 7 cases of bacterial pneumonia, 1 case of chronic bronchitis and 1 case of chronic cystitis at a daily dose of 1 to 4 grams twice a day for 2 to 15 days by intravenous drip infusion. The clinical response was excellent in 1 case, good in 2 cases and poor in 4 cases for7 cases of pneumonia, and good in each case of chronic bornchitis and cystitis.
Neither side effect nor abnormal laboratory findings were observed.
