1984 Volume 32 Issue Supplement9 Pages 654-662
The morphological changes in urinary microbes as well as the clinical evaluation were investigated after intravenous administration of a new cephalosporin antibiotic, AC-1370. The following results were obtained.
1. It was observed that E. coli in the urine is changed morphologically to spheroplast, ovoid cells and filament, which are known on the way to lysis. In S. marcescens, the formation of filamentous cells was induced by the antibiotic.
2. Clinical evaluation
The effective rates were 100% for simple UTI and 50% for complicated UTI cases.
