Abstract
In vitro antibacterial activity of sultamicillin (SBTPC) was assayed using ampicillin (ABPC) and BRL25000 as reference drugs.
1. SBTPC had a broad spectrum of in vitro antibacterial activity against 22 standard strains of 18 gram-positive and gram-negative species. The MIC levels of SBTPC were ranged from less than 0.05 to 12.5 μg/ml against most of strains tested. Similar results were obtained in BRL25000.
2. Against 15 kinds of species from clinical origin, each of which contained from 37 to 100 strains, SBTPC was potent except to 4 species of S. marcescens, P. aeruginosa, P.morganii and E cloacae. SBTPC was strongly potent against S. aureus, S. epidermidis, P. mirabilis and H. influenzae. These results were similar to that in BRL25000. Against other strains of species, SBTPC was moderately effective and the antibacterial activity against P. rettgeri, P. inconstans, C. freundii was much stronger in SBTPC than in BRL25000. SBTPC was effective to ABPC-resistant E. coli strains as well as BRL25000.
3. Eight among ten kinds of different β-lactamase-producing strains were sensitive to SBTPC, although their MIC levels of ABPC were more than 100 μg/ml. SBTPC as well as BRL25000 was not potent to cephalosporinaseproducing P. aeruginosa and S. marcescens strains but it was potent to cephalosporinase-producing P. morganii, to which BRL25000 was not effective. SBTPC was strongly potent against plasmid-mediated penicillinaseproducing strains.
