FUNDAMENTAL AND CLINICAL STUDY ON IMIPENEM/CILASTATIN SODIUM (MK-0787/MK-0791), CARBAPENEM ANTIBIOTICS, IN THE RESPIRATORY TRACT INFECTION
1985 Volume 33 Issue Supplement4 Pages 470-475
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1985 Volume 33 Issue Supplement4 Pages 470-475
To evaluate the effectiveness of antibiotics imipenem/cilastatin sodium (MK-0787/MK-0791), a derivative of carbapenem, for respiratory infection, following studies were performed: 1. Intrabroncho-alveolar concentration of drug with experimental animal. 2. Clinical study. 3 Number of microorganism in the sputum of a case of chronic bronchitis.
MK-0787/MK-0791 was intravenously injected into albino rabbits with which was broncho-alveolar lavage performed sequentially. MK-0787 was detected from 30 to 240 minutes after injection and the peak of concentration was observed at 60 minutes.
Clinical studies were tried with each two cases of bacterial pneumonitis, chronic bronchitis, each one of pulmonary suppuration and bronchiectasis combined with chronic respiratory failure. Good effectiveness were observed with all but one case of chronic bronchitis, with whom evaluation was fair.
Number of Pseudomonas aeruginosa in the sputum of a case of chronic bronchitis decreased from 5 ×105 to 2 ×104 per ml in four hours after intravenous injection.
As the side effect, skin eruption was observed in 1 case. Laboratory findings revealed 1 case with a slight increase in GOT and GPT.
