Abstract
80 women with acute uncomplicated cystitis were randomly allocated to treatment with the following oral dose of cinoxacin: A; 800mg single dose, B; 1, 600mg single dose, C; 400mg every 12 hours for 3 days, D; 400mg every 12 hours for 7 days. Eight women were excluded from the study. Of these, one was excluded because of loss to clinical follow-up, one because of negative urine culture on entrance into the study, and six because of resistance of initial microorganism to cinoxacin. Persistence of bacteriuria was observed in 2 of 19 patients and decrease of bacteriuria in one, in the 800mg single dose group. In the 1, 600mg single dose group and conventional treatment groups (800mg daily for 3-7 days), all of initial pathogens were eradicated.
There were no significant differences in the clinical efficacy between the treatment regimens. No significant difference was observed in the recurrence 7 days after treatment between the four treatment regimens.
We concluded that single dose therapy with cinoxacin for uncomplicated cystitis in women is as effective as conventional therapy with a 3-day or 7-day course of the same agent.
