EFFECT OF VARIOUS ANTIBIOTICS ON ANTIBODY PRODUCING CELLS OF MOUSE SPLEEN

(II) INFLUENCE OF SIDE CHAINS

Abstract

The influence of antibiotics on antibody production in the spleen was evaluated in mice immunized with sheep red blood cells.
In penicillins, enhancing effect on antibody production was observed, when 20 mg/mouse of ticarcillin was given in the immunized mice and considered due to the activity of thiophen radical of the antibiotic.
Ticarcillin did not act to B cells directly., a marked decrease in antibody producing cells was observed when cefsulodin was injected, effect of side structure of cephem antibiotic including cefsulodin on the antibody production of mouse spleen was investigated. It was suggested that the side structure of those antibiotics played an important role for the antibody production.