Abstract
One gram of 6315-S (flomoxef), a newly developed injectable oxacephem antibiotic, was given intravenously to 24 patients prior to abdominal total hysterectomy for uterine myoma. Bilateral uterine arteries were clamped at 0.25, 0.5, 1, 2, 4, 6 h after administration, and serum samples and uterine tissues were taken for the measurement of 6315-S concentration by bioassay.
We noted a slight difference in concentrations between cubital venous and uterine arterial serum, the half-lives being 1.2 and 1.0 h, respectively. The initial concentrations were estimated to be 87.4μg/ml and 95.6μg/ml, respectively.
Peak concentrations were obtained at 7.2 min in the myometrium and at c. 15 min in the other tissues, as follows: myometrium 33.7μg/g, oviduct 31.8μg/g, portio vaginalis 29.8μg/g, cervix uteri 29.6μg/g, endometrium 29.4μg/g, and ovary 27.0μg/g. Tissue concentrations thereafter decreased gradually in the same manner as did serum concentrations.
Judging from its favorable transfer into the uterine tissues and MIC's against clinical isolates often encountered in obstetrics and gynecology, 6315-S was evaluated as clinically useful in the treatment of obstetric and gynecological infections.
