BASIC AND CLINICAL STUDIES ON 6315-S, A NEW OXACEPHEM
1987 Volume 35 Issue Supplement1 Pages 599-603
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1987 Volume 35 Issue Supplement1 Pages 599-603
Distribution of 6315-S, a new oxacephem, in humans was studied by measuring its levels in serum and lung tissue of nine patients after a single 1 g i. v. injection. The penetration rate from blood into lung tissue was measured, and average ratios of tissue vs. blood level were 39.8% at 1 h, 49.5% at 2 h, and 61.2% at 3 h after i. v. administration.
6315-S was also given by drip infusion (2-4 g b. i. d. for 2 weeks) to 8 patients: 6 with pneumonia, 1 each with pulmonary suppuration and chronic bronchitis. Clinical effects were evaluated as good in 6 and poor in 2 patients. No side-effects occurred during treatment, but abnormal values in hepatic function tests were observed in 2 patients, which returned to normalafter cessation of therapy.
