1989 Volume 37 Issue 12 Pages 1467-1472
We made a clinical study of postoperative infection due to Pseudomonas aeruginosa in adult cases of digestive tract surgery from January 1985 to August 1988. Thirty-four strains of P.aeruginosa were isolated from 29 patients with postoperative infection. In these 29 cases, risk factors such as metachronous double cancers, diabetes mellitus, and hypertension were recognized in 4, 4, and 3 cases, respectively, and 22 (75.9%) were operated for malignant diseases. The blood-loss during the operation exceeded 1, 000 ml in 11 cases (37.9%) and antibiotics administered for prophylaxis were not effective against P.aeruginosa in 15 cases. The infections in 23 cases (67.6%) were related to the site of the operation, and intraabdominal sepsis and wound infection were frequent. The interval between surgery and onset was more than 8 days in 26 cases (76.5%). Ten strains (29.4%) were isolated along with other bacteria, and the incidence of mixed infections was high in cases of intraabdominal sepsis and wound infection. The minimum inhibitory concentrations (MICs) of P. aeruginosa, isolated from clinical cases from January 1985 to November 1988, were measured and compared with those isolated from 1982 to 1984. The MIC80, value decreased for piperacillin, cefsulodin, cefoperazone, ceftazidime and aztreonam, and increased for imipenem, amikacin, gentamicin, ofloxacin and ciprofloxacin.
