Abstract
The antibacterial activity of OPC-7251 was compared with that of tetracycline (TC), erythromycin (EM), clindamycin (CLDM), gentamicin (GM), norfloxacin (NFLX), ofloxacin (OFLX) and enoxacin (ENX). The results were as follows:
(1) OPC-7251 had a potent and broad spectrum of antibacterial activity against aerobic Grampositive, aerobic Gram-negative and anaerobic bacteria.
(2) OPC-7251 had potent antibacterial activity against clinically isolated strains of Propionibacterium acnes and Staphylococcus epidermidis, which are known as exogenous factors inacne vulgaris.
OPC-7251 also had potent antibacterial activity against clinically isolated strains of Staphylococcus aureus, methicillin-resistant Staphylococcus aureus and Pseudomonas aeruginosa.
(3) The antibacterial activity of OPC-7251 was augmented in an acidic medium and was little influenced by the inoculum size.
(4) The mode of antibacterial action of OPC-7251 was bactericidal.
(5) The incidence of bacterial strains which developed spontaneous resistance to OPC-7251 was low. OPC-7251 did not cause cross-resistance to NFLX, OFLX and ENX.
We therefore anticipate that OPC-7251 will show clinical efficacy in acne vulgaris and other skin infections.
