AZTREONAM CONCENTRATION IN SERUM AND BLADDER WALL TISSUE

Abstract

Aztreonam (AZT), a new kind of antibiotic which is fairly stable against β-lactamase, was tried on patients with benign prostatic hyperplasia (BPH) and its blood and bladder wall tissue levels were determined. The subjects were 11 patients with BPH who all underwent retropubic prostatectomy. As soon as the operation was started, 100 ml of saline solution in which 2 g of AZT had been dissolved was administered by intravenous drip infusion for 10 min. Sixty minutes after the infusion about 1 g of tissue was harvested across all layers of bladder wall, and 2 ml of blood was drawn at the same time. The mean tissue level was 65.4±13.6μg/ml, and the mean tissue level was 38.8±25.3μg/g, consistent with the reported transport of existing cephem antibiotics to the blood and bladder wall.