MICONAZOLE FOR DEEP-SEATED FUNGAL INFECTIONS ASSOCIATED WITH HEMATOLOGICAL DISEASES
A MULTI-INSTITUTE STUDY
1990 Volume 38 Issue 6 Pages 560-569
Details
1990 Volume 38 Issue 6 Pages 560-569
Miconazole was administered by intravenous infusion in 400mg doses two to four times daily to 103 patients with deep-seated fungal infections associated with hematological diseases. The mean duration of administration was 18.3±13.1 days. The data of 87 of these cases were used for analysis. The results were as follows.
1. Out of 87, marked efficacy was seen in 10 cases and efficacy in 45. The overall efficacy rate was 63 %, the efficacy rate in the group administered up to 800mg/day of miconazole was 50 %, and that in the group receiving more than 1, 200mg/day was 69 %.
2. The fungus was eliminated in 8 and reduced in 4 of the 23 cases in which mycological examination was done before and after treatment with miconazole.
3. In chest X-ray films of 42 cases, shadows disappeared in 2 and improved in 18.
4. Side effects occurred in 9 (8.7 %) of 103 cases, none of them being serious.
We consider miconazole a potent antifungal agent for treatment of deep-seated fungal infections associated with hematological diseases.
