1991 Volume 39 Issue 11 Pages 1034-1039
We studied the effect of combined therapy with cefodizime (CDZM), rG-CSF and γ-globulin on methicillin-resistant Staphylococcus aureus (MRSA) in cyclophosphamide-treated mice. Each mouse was inoculated with 5×106 cfu of MRSA. While CDZM with y-globulin (50 mg/kg) did not improve the survival rate of mice, CDZM withr G-CSF (30μg/kg) hada minimum effect, the survival rate being 0% for CDZM 250 mg/kg, 17% for 500 mg, and 17% for1, 500 mg. A combination of CDZM, rG-CSF and γ-globulin, however, had more effect as the dose of CDZM increased, the survival rate being 17% for 250 mg, 33% for 500 mg, and 67% for1, 500 mg. These results suggest that chemotherapy with biological response modifiers such as rG-CSF and γ-globulin is effective against MRSA in the immunocompromised host.
