PENETRATION OF CEFPIRAMIDE INTO POSTOPERATIVE WOUND EXUDATE

Abstract

We examined clinically the penetration of cefpiramide (CPM) into postoperative wound exudate. CPM was administered to 13 women after radical mastectomy on the first postoperative day, in three different ways:(a) bolus injection of 1g intravenously (1g i.v., n=5), (b) bolus injection of 2g (2g i. v., n=4) and (c) drip infusion of 2g for 60min (2g d.i., n=4).The concentration of the drug was measured by bioassay with the agar-well method. The maximum concentration and area under the curve of CPM in wound exudate were 13.8μg/ml, 184μg·h/ml (1g i.v.);32.0μg/ml, 422μg·h/ml (2g i.v.);and 29.2μg/ml, 363μg·h/ml (2g d.i.).That is, the higher the dose, the higher the concentration of CPM in wound exudate.And the results of 2gi.v. and 2g d.i. were similar to each other. The time-concentration curve of CPM in wound exudate showed a very gradual slope, namely, 5-6h was required to reach the peak, and the half-life of CPM in wound exudate was about 9h. The CPM concentration in wound exudate remained 30% of the peak level at 24h after administration. The CPM level remained higher than 12.5μg/ml (2g i.v., 2g d.i.) or 6.25μg/ml (1g i.v.) for 18h.