1991 Volume 39 Issue Supplement1 Pages 160-169
We conducted basic and clinical investigations on cefpirome (CPR), a newly developed cephem drug for injection, which yielded the following results.
1. When 0.5 g of CPR was intravenously administered in a 1-h drip infusion to three elderly patients (mean age 85 years), the mean blood concentration reached a peak of 45.2 μg/ml 1 h after administration, and the mean half-life was 3.6 h.
2. The mean urinary recovery rate until 24 h after administration was 72.1%.
3. The clinical response in 28 cases (22 of pneumonia, 1 of lower respiratory tract infection, 4 of urinary tract infection, and 1 fever of unknown origin), excluding 1 unassessable case of lung cancer, was excellent in 2, good in 15, fair in 5 and poor in 6, with an efficacy rate of 60.7%.
4. As to bacteriological effect, 11 of 17 strains were eliminated (64.7%) and 5 replaced, including one strain of Staphylococcus aureus and two strains each of Enterococcus faecalis and Pseudomcmas aeniginosa.
5. Side effects were noted in one case of consciousness disorder accompanying electrolyte anomalies. As abnormal laboratory findings, there were two cases of elevated GOT and GPT, one of elevatedeosinophils, and one of elevated GOT, GPT, Al-P and anemia. But all symptoms improved upon discontinuation or end of drug administration.
The above results suggest that CPR is cl useful drug against infections in the elderly, especially those involving the respiratory tract.
