1991 Volume 39 Issue Supplement1 Pages 243-252
Antimicrobial activities and clinical studies on cefpirome (CPR), a new injectable cephalosporin, were performed and the following results were obtained.
1. Antibacterial activity of CPR
Against 45-50 strains of 11 kinds of pathogens isolated from urine, CPR's activity was compared to those of ceftazidime (CAZ), cefmetazole (CMZ), latamoxef (LMOX), ampicillin (ABPC) and ofloxacin (OFLX). Against Escherichia coli and Ktebsiella pneumoniae, CPR was superior to CAZ, and against Proteus mirabilis and indole (+) Proteus spp., it was superior to CMZ, LMOX, ABPC and OFLX. But against Serratia marcescens and Pseudomonas aeruginosa, it showed weaker activity than CAZ.
2. Clinical efficacy
CPR was administered in a daily dose of 0.5g or 1.0g for 5 or 10 consecutive days to 16 patients. In 15 cases which were in accord with the Japanese UT! Committee, excellent results were observed in 5, moderate in 9 and poor in 1 case. The overall efficacy rate in bacteriological respons was 96.3%(26 of 27 strains eradicated). There were no adverse reactions though transient abnormal laboratory changes were observed in 6 cases (37.5%).
