Abstract
Clinical effect and excretion into peritoneal exudate of a new carbapenem antibiotic, panipenem/betamipron (PAPM/BP), were studied. PAPM/BP was given to 6 patients with surgical infections.
The clinical effects of PAPM/BP were good in 3, fair in 1 and poor in 2 patients. No side effects were observed. The concentration of panipenem (PAPM) in intraperitoneal exudate after gastrectomy was retained 1-2μg/ml for 3 days following gastrectomy, when given in a daily PAPM/BP dosage of 0.5g/0.5g×2 intravenously.
