1991 Volume 39 Issue Supplement4 Pages 93-100
Antichlamydial activity of sparfloxacin (SPFX) was examined in comparison with that of ofloxacin (OFLX) and minocycline (MINO) with the following results.
1. The MIC90 of SPFX for 37 clinical isolates of Chlamydia trachomatis was 0.063 μg/ml, while the MIC90s of OFLX and MINO were 1 and 0.031 μg/ml, respectively.
2. The minimum lethal concentration of SPFX for Chlamydia trachomatis D/UW-3/Cx was0.125 μg/ml, twice the MIC (0.063/μg/ml), while that of OFLX was 2μg/ml, twice the MIC (1μg/ml), and that of MINO was 0.25μg/ml, 8 times the MIC (0.031μg/ml).
3. Transmission electron microscopic observation revealed that SPFX and MINO specifically disrupted reticulate bodies but not elementary bodies. The degree of disruption of reticulate bodies was more marked under SPFX treatment (2 MIC) than under MINO treatment (2MIC).
These results indicate that SPFX is as potent as MINO as an antichlamydial agent.
