Meropenemの抗菌力とin vitro pharmacokinetic modelを用いた抗菌活性の検討

稲松 孝思; 深山 牧子; 増田 義重; 安達 桂子; 上條 仁子; 畠山 勤; 島田 馨; 後藤 元; 後藤 美江子

doi:10.11250/chemotherapy1953.40.Supplement1_67

IN VITRO ACTIVITY OF MEROPENEM AGAINST CLINICAL ISOLATES AND IN VITRO PHARMACOKINETIC MODEL

Takashi Inamatsu, Makiko Fukayama, Yoshishige Masuda, Keiko Adachi, Hitoko Kamijo, Tsutomu Hatayama, Kaoru Shimada, Hajime Goto, Mieko Goto

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Keywords: Pseudomonas aeruginsa, Staphylococcus aureus, enterococci, pharmacokinetic model

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1992 Volume 40 Issue Supplement1 Pages 67-73

DOI https://doi.org/10.11250/chemotherapy1953.40.Supplement1_67

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Abstract

The antibacterial activity of meropenem (MEPM), a newly developed carbapenem, against clinical isolates of Pseudomonas aeruginosa, Staphylococcus aureus and enterococci, was evaluated by MIC and the in vitro pharmacokinetic model. The MICs of MEPM against P. aeruginosa were lower than those of imipenem (IPM) and ceftazidime (CAZ). Evaluation of antipseudomonal activity of MEPM performed by the in vitro pharmacokinetic model showed larger bactericidal activity and a longer post-antibiotic effect than CAZ. The MICs of MEPM against S. aureus and Enterococcus faecalis were slightly higher than those of IPM.

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