PHARMACOKINETICS OF ME 1207, A NOVEL ORAL CEPHEMANTIBIOTIC, IN RATS

STUDIES ON MULTIPLE ADMINISTRATION PHARMACOKINETICS, PLACENTAL TRANSFER AND TRANSFER TO MILK USING (AMINOTHIAZOLE-2-¹⁴C) ME 1207

Abstract

Accumulation, placental transfer and transfer to milk of ME 1207 were studied in rats after oraladministration of (Aminothiazole-2-¹⁴C) ME 1207 at a dose equivalent to 20 mg of ME1206/kg.
1. No accumulation of radioactivity was observed in blood or tissues after multiple oral administration (20mg/kg once a day for 21 days).
2. The radioactivity was scarcely transfered to the fetus after single oral administration to 13-day- and 18-day-pregnant rats.
3. The radioactivity concentration in the milk was much lower than the plasma concentrationafter single oral administration to nursing rats.