1992 Volume 40 Issue Supplement2 Pages 87-92
The antimicrobial activity of ME 1207 was determined using the urinary samples recovered in the Phase I study. A dose of 200mg of ME 1207 or cefteram pivoxil (CFTM-PI) was administrated three times per day to 8 adult healthy male volunteers by the cross-over method. The urinary samples were recovered on time. The mean peak of urinary levels for the ME 1207 group was 183μg/ml (2-4h) and 227μg/ml (2-4h) for the CFTM-PI group. Antibacterial activity and bactericidal activity in urine against Staphylococcus epidermidis, Escherichia coli, Klebsiella pneumoniae and Serratia marcescens were determined with the above urinary samples. Antibacterial activity and bactericidal activity in the ME 1207 group against S. epidermidis in urine were superior to those in the CFTM-PI group. Against E. coli, K. pneumoniae and S. marcescens, the antibacterial activity and bactericidal activity in the ME 1207 group in urine were almost as strong as those in the CFTM-PI group.
