Clinicobacteriologic study of sultamicillin fine granules for pediatric acute suppurative otitis media

Abstract

Clinical studies of the effectiveness sultamicillin fine granules (SBTPC FG) on acute suppurative otitis media in children were performed.
1. SBTPC FG was administered to 127 children with acute suppurative otitis media and its clinical efficacy was 97.6%. This ratio was similar to the Expected Efficacy Index (EEI) of sultamicillin.
2. Clinical efficacy for the 167 strains of bacteria isolated was 98.8%.
3. Major pathogens were Streptococcus pneumoniae and Haemophilus influenzae.
4.24% of the S. pneumoniae strains isolated were PCG insensitive S. pneumoniae (PISP) and were the primary infections agent (11% of all patients).
5. 52 (31.1%) of the 167 strains isolated from middle ear discharge and 93 (46.0%) of the 202 strains isolated from nasopharyngeal swabs were β-lactamase producers.
6. Side effects occurred in 25 of the 128 patients assessed, an incidence of 19.5%. Diarrhea developed in 23 patients (18.8%). The incidence of diarrhea was higher in those under three years of age.
7. SBTPC FG was concluded to be very effective for the treatment of acute suppurative otitis media in children.