Abstract
Pharmacokinetics studies of S-1108, an ester-type oral cephem antibiotic, were evaluated in 5 elderly patients (mean aeg: 76y). The plasma concetrations and urinary excretions of S-1006, the active compound of S-1108, were measured after 100mg administration under non-fasting conditions. The peak plasma levels were 1.35-2.60μg/ml at 2-3 hours after administration, and in 2 patients of moderate real failure (mean S-Cr: 2.1mg/dl) the levels were 1.67 and 2.60μg/ml which were higher than those in 3 mind renal failure patients (mean S-Cr: 1.0). The mean Cmax, urinary excretions, T1/2 and AUC were 1.73μg/ml, 26.5%, 1.79 hr and 8.18μg·hr/ml, respectively, indicating the adsorptions was delayed a little and urinary excretion was also lower compared with young adult volunteers.
