Transfer of aspoxicillin to the bronchoalveolar system
1994 Volume 42 Issue 12 Pages 1391-1396
Details
1994 Volume 42 Issue 12 Pages 1391-1396
I studied the transfer of aspoxicillin (ASPC) to the bronchoalveolar system, using bronchoalveolar lavage (BAL), and compared the findings with my previous results for cefmenoxime (CMX), astromicin (ASTM), ofloxacin (OFLX) and aztreonam (AZT). The subjects were 22 patients with various respiratory diseases: 14 with chronic respiratory infection and 4 each with interstitial pneumonia and lung cancer. 1g of ASPC was given intravenously in group I, and with 1g of CMX in group II. BAL was performed 60 minutes after a single intravenous injection of ASPC. The concentrations of ASPC, CMX total protein and albumin were measured in serum and bronchoalveolar lavage fluid (BALF), and the following results were obtained.
1) The concentration of ASPC was 11.2-69.8μg/ml in serum, and 0.071-1.420μg/ml in BALF, the mean values±standard deviation being 37.53±17.3μg/ml and 0.307±0.409mg/ml, respectively.
2) The concentration of CMX was 24.7-61.8μg/ml in serum, and 0-0.77μg/ml in BALF, the mean values±standard deviation being 41.4±14.9μg/ml and 0.209±0.241μg/ml, respectively.
3) Thus, transfer of ASPC was superior to that of CMX, and next to those of OFLX and ASTM in my previous study.
