Study on in vivo postantibiotic effect of biapenem, a carbapenem antibiotic

Abstract

In vivo postantibiotic effect (PAE) of biapenem (BIPM), a new carbapenem antibiotic, was investigated.
When an antibiotic was administered at a dose 50mg/kg to thigh infection model of mice with neutropenia, in vivo PAE on Staphylococcus aureus Smith was determined to be 3.0hours for BIPM, 2.7 hours for imipenem/cilastatin (IPM/CS), and 0.8 hour for cefazolin (CEZ).
The PAE at 50mg/kg on Klebsiella pneumoniae BK was determined to be 1.7hours for BIPM, and 0.5hour for IPM/CS.
On Pseudomonas aeruginosa ATCC 27853, that was determined to be -1.5hours for BIPM, and-0.8hour for ceftazidime.