新しいカルバペネム系抗菌薬biapenemに関する基礎的・臨床的検討

稲松 孝思; 深山 牧子; 増田 義重; 佐野 靖之; 宮本 康文; 荒井 康男; 荒井 千明; 田中 康子; 島田 馨

doi:10.11250/chemotherapy1953.42.Supplement4_330

Laboraroty and clinical study on biapenem, a new carbapenem derivative

Takashi Inamatsu, Makiko Fukayama, Yoshishige Masuda, Yasuyuki Sano, Yasufumi Miyamoto, Yasuo Arai, Chiaki Arai, Yasuko Tanaka, Kaoru Shimada

Author information

Takashi Inamatsu
Infectious Disease Section, Tokyo Metropolitan Geriatric Hospital
Makiko Fukayama
Infectious Disease Section, Tokyo Metropolitan Geriatric Hospital
Yoshishige Masuda
Infectious Disease Section, Tokyo Metropolitan Geriatric Hospital
Yasuyuki Sano
Department of Allergy and Respiratory Disease, Doai-Memorial Hospital
Yasufumi Miyamoto
Department of Allergy and Respiratory Disease, Doai-Memorial Hospital
Yasuo Arai
Department of Allergy and Respiratory Disease, Doai-Memorial Hospital
Chiaki Arai
Department of Allergy and Respiratory Disease, Doai-Memorial Hospital
Yasuko Tanaka
Department of Allergy and Respiratory Disease, Doai-Memorial Hospital
Kaoru Shimada
Department of Infectious Disease and Applied Immunology, Institute of Medical Science, University of Tokyo

JOURNAL FREE ACCESS

1994 Volume 42 Issue Supplement4 Pages 330-336

DOI https://doi.org/10.11250/chemotherapy1953.42.Supplement4_330

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Abstract

We evaluated the clinical efficacy and safety of biapenem (BIPM), a new carbapenem, in 25patients. Clinical evluation was carried out in 21 patients (sepsis 1, pneumonia 7, pulmonary suppuration 1, pyothorax 1, chronic bronchitis 8, bronchiectasis 2, cholecystitis 1). Clinical response was excellent in 7, good in 12, fair in I and poor in 1 case, on overall efficacy rate of 90.5%. Abnormal laboratoy findings were elevated GOT·LDH in 1 and eosinophilia in 1 patient.
From these result, BIPM was thought to be highly useful for the treatment of aged patients with various infectious disease.

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