1994 Volume 42 Issue Supplement4 Pages 37-54
We compared the in vitro and in vivo antibacterial activities of biapenem (BIPM) with imipenem/cilastatin (IPM/CS), cefpirome (CPR), ceftazidime (CAZ), aztreonam (AZT) and cefuzonam (CZON).
The in vitro activity of BIPM against gram-positive and gram-negative organisms was potent and almost the same as that of IPM.
Especially, against the glucose-nonfermentative bacteria including Pseudomonas spp., the activity of BIPM was higher than that of IPM.
BIPM showed a potent bactericidal activity and this activity was enhanced in presence of fresh mouse serum.
In experimental mice infections of various organisms, the therapeutic effect of BIPM was superior to IPM/CS, though BIPM and IPM were similar in in vitro antibacterial activities.
Especially, the efficacy of BIPM was remarkable in Pseudomonas aeruginosa infection.
Against respiratory tract infection with Klebsiella pneumoniae 3K25, the significant reduction level in the number of lungs organisms achieved by BIPM was almost the same as that of IPM.
In urinary tract infection with P. aeruginosa KU-1, the therapeutic effect of BIPM was superior to that of the reference antibiotics because viable cells in the kidneys decreased rapidly treated with BIPM.
