Basic and clinical studies on biapenem in genito-urinary infections
Keywords:
Biapenem
1994 Volume 42 Issue Supplement4 Pages 486-496
Details
1994 Volume 42 Issue Supplement4 Pages 486-496
We studied the antibacterial activity and clinical efficacy of biapenem (BIPM), a new carbapenem antibiotic, in the genito-urinary, infections.
1) Antibacterial activity: We measured the MICs of BIPM against clinical isolates (210 strains of 14 species) from urinary tract infections, and compared them with those of imipenem (IPM), ceftazidime (CAZ), latamoxef (LMOX) and cefoperazone (CPZ). In general, antibacterial activities of BIPM were almost equal to those of IPM, but superior to those of other control drugs.
2) Clinical efficacy: According to the criteria of Japanese UTI committee, the overall clinical efficacy rate was 73.9%(17/23) for chronic complicated UTI. Bacteriologically, 30 of 35 strains (85.7%) were eradicated.
3) Side effect: Clinical side effects and abnormal laboratory changes were not observed in any cases.
