Influence of human albumin on antibacterial activities of biapenem

Abstract

We investigated the in vitro antibacterial activity of biapenem (BIPM), imipenem (IPM), penicillin G (PCG) and ampicillin (ABPC) with the presence of human serum albumin.
As the test organism, Staphylococcus aureus ATCC 25923, Eschrichia coil ATCC 25922, three clinical isolates of Streptococcus anginosus and three clinical isolates of Streptococcus sanguis were used.
The MICs and MBCs of several agents against these strains were measured in Mueller-Hinton broth with or without 5g/dl of human serum albumin by the broth dilution method.
The presence of human serum albumin in the medium influenced the antibacterial activity of PCG, whereas not those of biapenem, IPM and ABPC.