Clinical Studies on biapenem in Obstetrics and Gynecology

Abstract

Biapenem (BIPM), a newly developed injectable carbapenem antibiotic, was studied to determine its usefulness in the fields of obstetrics and gynecology. The results of the study were as follows:
1) The subjects consisted 14 patients with intrauterine infection (n=7), adnexal infection (n=4), intrapelvic infection (n=3). Evaluating clinical efficacy, BIPM was administered drip infusion of 0.6-1.2g/day for 3 to 7 days (total doses of 1.5 to 6.0g).
2) Clinically, one case (salpingitis) was judged as excellent, 13 (intrauterine infection and other) as good, resulting in a total effective rate of 100%. Bacteriological effectiveness corresponded to 7/7 (100%).
3) Neither subjective nor objective side effects were observed, except for one case with increased level of eosinophilie.
These results suggest that BIPM appears to be useful against obstetrics and gynecological infections.