Clinical study of biapenem in patient with gynecologic infections

Abstract

Biapenem (BIPM) is a new 4-methyl carbapenem antibiotic with an exceptionally broad spectrum of an antibacterial activity in vitro and is stable to human renal dehydropeptidase -I (DHP-I). In this study, BIPM was intravenouslly administered to 4 patients with acute salpingitis at a dose of 300mg, 2 times for 4 to 6 consecutive days.
The clinical effects of BIPM were estimated to be excellent in 2 cases and good in 2 cases as for bacterial effect, three strains, Corynebacterium sp., Prevotella bivia and Bacteroides melaninogenicus, were eradicated after treatment. No side effects or abnormal laboratory test values were observed. Ultimately, BIPM were very useful for gynecologic infections.