Relationship between gallbladder tissue penetration of ceftriaxone and pathological findings

Abstract

For 36 patients undergoing cholecystectomy, a single 2g dose of ceftriaxone (CTRX) was administered by intravenous infusion prior to surgery. Following surgery, for each tissue sample obtained from the collum, corpus, and fundus of each surgically resected gallbladder, the tissue concentration of CTRX was individually determined. Additionally, ten pathological factors were selected, and the relation ship between pathological findings in each tissue sample and the effects exerted by the pathological factors on tissue concentration and tissue penetration of CTRX were investigated by multiple regression analysis. Pathological factors which were considered to affect the tissue concentration in the collum were local accumulation of inflammatory cells, the presence or absence of erosion, and the extent of wall hypertrophy. In the fundus, factors which were found to influence tissue concentration were the presence or absence of acute inflammation, the presence or absence of erosion, and the extent of wall hypertrophy. In the corpus, no significant relationship was observed between the tissue concentration of CTRX and the pathological factors. Penetration of CTRX into gallbladder tissue was extremely good, and the wet weight concentrations of CTRX in the collum, corpus, and fundus were high at 279.6μg/g, 239.1μg/g, and 265.8μg/g, respectively. Following administration of CTRX, no adverse reactions, no abnormalities in laboratory data, and no postoperative infections were observed.