1995 Volume 43 Issue 4 Pages 416-420
The protective effect of tazobactam/piperacillin (TAZ/PIPC) against the nephrotoxicity of gentamicin (GM) was examined in rats. Nephrotoxicity was induced by the intramuscular administration of GM at a dose of 70mg/kg/day for 10 days. TAZ/PIPC (1, 000mg/kg/day) and PIPC (800mg/kg/day) were intravenously administered, and then GM was immediately administered. Rats receiving GM (70 mg/kg/day) for 10 days showed increases in urinary Nacetyl-β-D-glucosaminidase (NAG), protein and β2-microglobulin, elevation of serum urea nitrogen and creatinine concentration, and showed an increase in kidney weight in comparison with controls. Macroscopic fading in the color of the kidneys was seen. Histologically, cortical tubular necrosis, desquamation and regeneration, tubular dilatation, hyaline cast formation and interstitial inflammatory cell infiltration were seen. However, TAZ/PIPC and PIPC significantly reduced these toxicological parameters. These results suggest that TAZ/PIPC may have a protective effect against the nephrotoxicity of GM in rats, and the degree of this protective effect was equal to that of PIPC.
