1995 Volume 43 Issue 4 Pages 457-461
The prophylactic effects of G-CSF against postoperative infection after trans-urethral resection of the prostate were examined in two comparative studies. Lenograstim was administered for 5 consecutive days in the perioperative period; the administration of G-CSF was started the day before the operation in study A and two days after the operation in Study B. In the G-CSF treatment groups, the incidences of postoperative infection were 33.3% (3/9) and 21.1% (4/19), respectively. The incidences of postoperative infection were 37.5% (3/8) and 46.7% (7/15) in both control groups. The incidence of uropathogenic gram-negative rods among positive isolates was 28.6% (2/7) for the treatment groups and 60.0% (6/10) for the control group. No adverse reactions related to neutrophilia and overproduction of superoxide caused by the administration of G-CSF were observed, although transient urticaria was noted in one patient.
